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ADHD Treatment For Adults stimulants such as amphetamine and methylphenidate increase the levels of certain brain chemicals. Nonstimulants, like atomoxetine and antidepressants, work more slowly than stimulants but may also be helpful. Complicating conditions often affect the response to ADHD medication. Doctors should treat the most severe symptom of any comorbid disorder first, and then check to see if the ADHD symptoms improve. Medication Adults with ADHD are usually treated with medication.