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Despite remarkable effectiveness, utilization of FMT treatments are limited as well as the method of action continues to be defectively recognized. Here, we show a critical role for the immunity in supporting FMT using a murine C. difficile infection system. Following FMT, Rag1 heterozygote mice resolve C. difficile while littermate Rag1-/- mice fail to clear the disease. Targeted ablation of transformative immune cellular subsets expose a required part for CD4+ Foxp3+ T-regulatory cel