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How Does ADHD Medication Work? ADHD is treated by taking stimulants. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons in order to improve attention and decrease excessive hyperactivity. However, as much as 20% of people do not respond to the most commonly prescribed stimulants, methylphenidate or amphetamine. This could be due to their body chemistry or other medications they are taking. What are the signs of ADHD? Talk to your child's