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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is particularly the case when they fail to achieve their goals in terms of personal and professional. It aren't always easy to determine when there are symptoms that overlap between ADHD and depression. Recognizing the symptoms is a good first step to getting treatment. 1. Feelings of unworthiness Many people who have untreated ADHD or depres