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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a myriad of issues for adults. These issues can affect work, relationships, and mental health. Most people with untreated ADHD have low self-esteem as well as a negative perspective on the world. This can cause them to feel like they're failing at work and home. Inattention and lack of Focus It is normal to have trouble focusing from time-to-time particularly after a hectic day at work or at school. If