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The pooled sensitivity, specificity, positive likelihood ratio, and pooled negative likelihood ratio of nCLE in detecting gastric disorders were 90%, 96%, 20.4, and 0.11, respectively. The pooled sensitivity and specificity showed a substantial heterogeneity. An ROC curve was constructed with an area under the curve (AUC) of 0.94. The overall AEs rate of pancreatitis was 2.7%. We showed that nCLE had a relatively high sensitivity and specificity for diagnosing PCLs with a relatively low rate of AEs occurring. We