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Japan's voyage towards economic progress and stability will be a complex narrative that intertwines historic challenges with contemporary aspirations. As the world’s third-largest economy, Japan stands in a critical crossroads where standard economic strategies need to adapt to modern-day issues. The nation's prolonged struggle using deflation, an growing older population, and escalating public debt has created a fragile circumstance that demands very careful navigation. Every decision made by policymakers, from fiscal measures to adj

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Atopic dermatitis (AD) represents a severe global burden on physical, physiological and mental health. Innate immune cell basophils are essential for provoking allergic inflammation in AD. However, the roles of novel immunoregulatory cytokine IL-37 in basophils remain elusive. We employed in vitro co-culture of human basophils and human keratinocyte HaCaT cells and an in vivo MC903-induced AD murine model to investigate the anti-inflammatory mechanism of IL-37. In the in vitro model, IL-37b significantly decreased Der p1-induced thymic