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Also, the more the sheer number of medications utilized concomitantly with ICIs, the bigger the risk of demise (1 medication hazard proportion, 1.88; CI 95percent, 1.07-3.30; 4 drugs hazard proportion, 4.19; CI9 5%, 1.77-9.92; P less then .001). CONCLUSION a reaction to ICIs is influenced by making use of medications that result in abdominal dysbiosis. Although a confirmatory prospective controlled study is necessary, our findings should always be taken into account whenever examining ICI effectiveness