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Model based arterial and portal vein input functions were automatically determined during the joint direct parameterization. Observations made on simulated fully and highly undersampled liver DCE MRI data were confirmed on acquired clinical data. INTRODUCTION Oral squamous cell carcinoma (OSCC) is the seventh most common cancer globally, and has been identified as a growing health concern. This study aims to evaluate the current literature comparing elective neck dissection to observation in the treatment of early-stage tongue SCC, foc