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We compared the bioengineered tumors with patient tumors and found all of them to recapitulate the pathology and immunophenotyping associated with the patient tumors a lot better than the PDX model created through the exact same SCLC mobile range. Whenever treated with standard chemotherapy medications, etoposide and cisplatin, the organoid recapitulated relapse after chemotherapy. Co-culture regarding the SCLC cells with ALFs disclosed that the fibroblasts perform an integral rol