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The mitochondria are a major source of reactive oxygen species (ROS). Superoxide anion (O2•-) is produced by the process of oxidative phosphorylation associated with glucose, amino acid, and fatty acid metabolism, resulting in the production of adenosine triphosphate (ATP) in the mitochondria. Excess production of reactive oxidants in the mitochondria, including O2•-, and its by-product, peroxynitrite (ONOO-), which is generated by a reaction between O2•- with nitric oxide (NO•), alters cellular function via oxidative modification of pr