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All noncongenital cases had at least one pathogenic variant in one of the final three TTN exons (362-364). Our findings suggest a novel association between the location of nonsense variants and the clinical severity of the disease. Our findings suggest a novel association between the location of nonsense variants and the clinical severity of the disease.The formation of amyloid deposits in human tissues is a defining feature of more than 50 medical disorders, including Alzheimer's disease. Strong genetic and histological evidence links th