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07±3.01years; range, 1.00-13.99years). Tooth extraction within 7days before RT was not associated with increased ORNJ risk (hazard ratio [HR] =0.734; P=.312). Significant risk factors for ORNJ included oral cancer (adjusted HR=3.961), tumour excision surgery within 3months before RT (adjusted HR=3.488) and mandibulectomy within 3months before RT (adjusted HR=5.985; all P.001). In a mean follow-up of 4years, tooth extraction within 7days before RT for HNC treatment did not increase the ORNJ risk compared with tooth extraction 7-21days
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