https://akt-signal.com/index.p....hp/pb-doped-ag2-ze-m
Here, we performed screening for tiny molecules that control human IP5K activity, revealing that the antiparasitic medicine and polysulfonic element suramin efficiently inhibits IP5K in vitro as well as in vivo. Results from docking experiments and biochemical validations advised that suramin targets IP5K in a definite bidentate manner by concurrently binding to your ATP- and IP5-binding pouches, thus inhibiting both IP5 phosphorylation and IP5-independent ATP hydrolysis. NF44
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