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The trends obtained from both SOD and GSH assays were indicators of therapeutic defence against oxidative stress via neutralizing superoxide anions (SOA).To expand the structural diversity and optimize the material performance, it is essential but challenging to regulate MOF structures in a predictable and controllable manner. In this work, by manipulating the substituents to engineer the ligand conformations, we designed and synthesized two asymmetric tricarboxylate ligands, and used them to successfully target two copper-tricarboxylate