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, 6 months after baseline). A repeated measures ANOVA showed a significant difference after treatment on depression levels, levels of self-esteem, and all dimensions of quality of life, such as physical, psychological, social relationships, and environment. Furthermore, a statistically significant difference on levels of CRP was found. Moreover, at follow-up, improvements were maintained. The study revealed initial evidence of the efficacy of a functional therapy program on treating depression and its psychological and inflammation-rel