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First Line Treatment For ADHD in Adults Certain people suffering from ADHD are able to use medications to manage their symptoms. Stimulants, like methylphenidate and amphetamine, work by increasing activity in the brain regions that regulate attention and behavior. Other medications, such as the nonstimulant drug atomoxetine, and antidepressants that work differently, but they are effective. Regular visits to the GP are recommended for those who are taking medication. They can adjust dosages and observe the bo