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rse populations suggest a role for artificial intelligence in the detection of glaucoma in primary care. To compare frequently used classification systems for age-related macular degeneration (AMD) in their abilty to predict late AMD. In total, 9066 participants from the population-based Rotterdam Study were followed up for progression of AMD during a study period up to 30 years. AMD lesions were graded on color fundus photographs after confirmation on other image modalities and grouped at baseline according to six classification syste