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SIRT3 can deacetylate the transcriptional facets and crosstalk with different signaling pathways to cooperatively modulate mitochondrial functions and control defensive mitochondrial quality control (QC) systems. Down-regulated NAD+ level and reduced SIRT3 task are regarding process of getting older and has now been pathologically connected to PD pathogenesis. More, SIRT3 can bind and deacetylate PTEN-induced kinase 1 (PINK1) and PD protein 2 E3 ubiquiti