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The roles of estrogen receptors (ERs) and the efficacy of anti-estrogen (E2) therapies in pancreatic cancer stay controversial. The main objectives of this study were to investigate the potential roles of ERs in tumor progression and endocrine therapies. The ER expression status in PANC-1 and SW1990 pancreatic cancer cell lines was determined. SRB assay, colony formation assay and proliferation assay were used to investigate the responses of these cells to E2. ERα-selective agonist propylpyrazoletriol (PPT), ERβ-selective agonis

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What Is a Sex Machine? A sexual machine is a mechanical device that allows for penetration of the body, typically with a dildo. It is typically made of a medical-grade, body-safe material like silicone. Sex machines are fantastic for enhancing masturba