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n Society for Microbiology.The anaphase promoting complex or cyclosome (APC/C) is a large E3 ubiquitin ligase, composed of 14 subunits. The activity of APC/C oscillates during the cell cycle to ensure a timely transition through each phase by promoting the degradation of important cell cycle regulators. Of the human herpesviruses, cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) both impair the activity of APC/C during their lytic replication through virus-encoded protein kinases. Here, we addressed if the oncogenic Kaposi sarcoma her
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