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414, 95% CI -0.740 to -0.087, p=0.013). The subgroup without psychiatric comorbidities ( =4, Hedges' =-0.479, 95% CI -0.801 to -0.156, p=0.004) was associated with significantly better improvement in fatigue severity with BWL than with DRL. In contrary, BWL was not associated with significantly different changes in depression severity or quality of life compared with DRL. Finally, BWL was associated with similar acceptability (ie, dropout rate) and safety profile (ie, any discomfort) as those of DRL. This meta-analysis provides an updat