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In addition, a logistic regression analysis revealed that the task performance improves as the timing of delta-beta PAC in the right temporal pole (TP) got closer to the trough position (180 degrees). CONCLUSION These results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents. © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.Bioorthogonal chemistry holds great potential to generate difficult-to-access protein-protein conjugate ar