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BACKGROUND Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. AIMS We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism. METHODS In a double-blind, randomized cross-over study, normolipidemic adults (n = 3 consumed 12 g/day of EPA-rich (EPA/DHA 2.3) or DHA-rich (EPA/DHA 0.3) fish oil for 8-weeks, separated by an 8-week washout perio