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05). CsA inhibited the expression of most genes associated with inflammatory response in NHDFs. There were only 19 genes with a fold change (FC) lower than -2.0, among which EGR1, FOS, PBK, CDK1 and TOP2A had the lowest expression, as did CXCL2 which can directly impact inflammation. Furthermore, ZNF451 was strongly induced, and COL1A1, COL3A1, IL33, TNFRSFs were weakly upregulated (FC lower than 2.. CONCLUSION The CsA in therapeutic concentration influence the genes linked to inflammatory response (in the transcriptional level) in h