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This article has an associated 'The people behind the papers' interview. The coronavirus disease pandemic has disproportionately affected poor and racial/ethnic minority individuals and communities, especially Indigenous Peoples. The object of this study is to understand the spatially varying associations between socioeconomic disadvantages and the number of confirmed COVID-19 cases in New Mexico at the ZIP code level. We constructed ZIP code-level data (n=372) using the 2014-2018 American Community Survey and COVID-19 data from the