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Their particular antiproliferative tasks against individual tumefaction cells were examined by MTT assay. The outcome demonstrated that many associated with the synthesized substances had antiproliferative effects comparable to the research medications gefitinib and lapatinib. In particular, (5 R )-5-(3-chloro-4-((5-(4-fluorophenyl)thiophen-2-yl)methyl)anilino)-1,2- O -isopropylidene-α-glucofuranose ( 9da ) showed the most potent antiproliferative results against SW480, A431 and A549 cell