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To compare the F-NaF PET/CT studies ( F-NaF) with other imaging methods in the detection of skeletal metastases (SM) in patients with medullary thyroid cancer (MTC). We retrospectively analyzed 31 patients with MTC who performed F-NaF to assess SM. The results of the F-NaF were compared with other imaging methods performed for metastasis detection Tc-MDP bone scan (BS), magnetic resonance imaging (MRI), contrast-enhanced CT (CT), and Ga-Dotatate and F-FDG PET/CT studies. A qualitative analysis comparing the F-NaF findings with the ones of