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The inclusion of anatomical information improves both accuracy and generalization. For an activity profile with an SNR of ~4, the framework is able to obtain an MRE of ~0.99% over the whole range and a range uncertainty of ~0.27 mm. The machine learning-based framework may emerge as a useful tool to allow for online dose verification and quality assurance in proton therapy.Research suggests that physical activity (PA) has many health benefits for an aging population. Evidence exploring the association between PA and vision is limited