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EC33 is a potent inhibitor of brain APA tested in pet models. Making use of EC33 in conscious spontaneously hypertensive rats, hypertensive deoxycorticosterone acetate-salt rats, and conscious normotensive rat designs causes a reduction in BP. So that you can facilitate the passage through of EC33 through the blood-brain buffer, the two particles of EC33 had been linked by a disulfide bridge to create a prodrug called RB150. RB150, later renamed as QGC001 or firibastat, had been found to b
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