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When coupled to resveratrol biosynthesis enzymes, the biosensor can sense changed resveratrol manufacturing in cells, demonstrating a 667-fold enrichment in a single round of fluorescence-activated cellular sorting. Our biosensor is likely to be possibly applicable to metabolic manufacturing of microbial cell production facilities for production of stilbenes and cannabinoids.This work reports halogenated 5-(2-hydroxyphenyl)pyrazoles as pseudilin analogues