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3%(N=19) of these areas did not change in shape or size over time, 58.7%(N=44) showed regressive changes, and 16.0%(N=12) showed progressive changes, of which thickening in all 12 of these patients showed an increase in the largest dimension by ≥2mm. Among the 78 patients, 7.7%(N=6) had biopsy-proven recurrence along the staple-line. An increase in the largest-dimension by ≥2mm (83.3% vs. 9.7%,p=0.001) and radiologic concern for malignancy (66.7% vs 11.1%,p=0.001) predicted staple-line recurrence. CONCLUSIONS Staple-line thickening is a