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All materials exhibited increasing PC deposition over time. Conventional hydrogel materials showed significantly lower PC uptake rates (P .001) than any of the SH materials. Increasing lipid concentration in the ATS resulted in increased PC binding onto the contact lens materials (P .001). Replenishing the ATS every other day, however, impacted the PC deposition differently, showing increased binding (P .001) on CHs and reduced PC deposition for SH materials (P .001). Length of incubation, lipid concentration in the

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The results indicated that drug loading, particle size, and solubility were mainly affected by RSV loading, PEG concentration, and Kolliphor EL concentration. The polymer contributed dominantly to reducing the particle size and enhancing solubility in this screening design. The presence of surfactants in this system made it possible to prolong the supersaturation process. According to the 26-2 FFD, the factors selected to be further developed using a statistical technique according to the quality-by design-approach, Box Behnken Desig