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Stapled peptides modeled following the E2 alpha-1 helix bound to your E1 groove, induced a consequential conformational change and inhibited E1 ubiquitin thiotransfer, disrupting E2 ubiquitin charging and ubiquitination of cellular proteins. Hence, we offer a blueprint for a definite E1-targeting strategy to treat cancer.Currently approved protected checkpoint inhibitor therapies targeting the PD-1 and CTLA-4 receptor pathways tend to be effective treatment options for certain cancers; but, most clients across cancer tumo
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