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Purpose To evaluate macular thickness fluctuations in patients with retinal vein occlusions (RVO) treated with anti-vascular endothelial growth factor (anti-VEGF) agents, and to assess whether patients with larger fluctuations have poorer visual outcomes. Design Retrospective cohort study PARTICIPANTS Treatment-naïve patients with RVO followed over 12 months of treatment METHODS From optical coherence tomography (OCT), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were collected at baseline, 3