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In capacitated human spermatozoa, we monitored Ca dynamics and the occurrence of the AR in real time using Fluo 3-AM and FM4-64 in a Ca -free medium. Epac activation by 2'-O-Me-cAMP induced a Ca wave that started in the midpiece and propagated to the acrosome region. This Ca response was sensitive to rotenone, CGP, xestospongin, NED-19, and thapsigargin, suggesting the participation of different ion transporters (mitochondrial complex I and Na /Ca exchanger, inositol 3-phosphate receptors, two-pore channels and internal store Ca -ATPases
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