https://www.selleckchem.com/pr....oducts/ono-7300243.h
In both groups, poorer performance was associated with increases in functional activation consistent with dedifferentiation. Moreover, there were age-related differences in the strength of these correlations, with better performing younger adults modulating the bilateral insula and temporal pole and better performing older adults modulating bilateral frontal pole and precuneus. Overall, these findings highlight the influence of task difficulty on fMRI activation in older adults and suggest that as task difficulty increases, older an
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