https://amonafideinhibitor.com..../relevance-regarding
Substances 1-5 and 7 featured an additional eight-membered O-heterocycle that has rarely been reported for ansamycins, in addition to Z,Z- and E,E-configurations for Δ2,Δ4 were reported for the first time in geldanamycin analogues. Substance 1 exhibited weak inhibition activity towards Hsp90α with an IC50 value of 96 µM, 2-5 showed mild cytotoxicity against four real human cancer tumors cellular outlines with IC50 values ranging from 13 μM to 86 μM, and 7 had moderate anti-HSV-
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