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IOP decreased during eyelid closure, which was significantly lower than downgaze at 25° (mean ± SEM -2.1 ± 0.3 mmHg vs. -0.7 ± 0.2 mmHg, P = 0.014). Our data suggest that IOP varies reproducibly with gaze direction, albeit with patient variability. IOP generally increased in upgaze but decreased in inferonasal gaze and on eyelid closure. Future studies should investigate the patient variability and IOP dynamics. Our data suggest that IOP varies reproducibly with gaze direction, albeit with patient variability. IOP generally increased in
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