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The frequency of aberrant SMARCA4 immunoexpression of a sarcomatoid or rhabdoid component in clear mobile RCC (ccRCC) (47/50, 94%) had been considerably greater than that in non-ccRCC (4/9, 44%) (p less then 0.001). In ccRCC without sarcomatoid or rhabdoid features, aberrant SMARCA4 immunoexpression was noticed in 33 of 48 (67%) cases. Immunoreactivities for SMARCB1, SMARCA2, and SMARCC2 had been retained in almost all subtypes of RCC. The clients with aberrant SMARCA4 appearance in RCC