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Copyright © 2020 Hermiz, Hossain, Arneodo, Ganji, Rogers, Vahidi, Halgren, Gentner, Dayeh and Gilja.Background Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel. Importantly, recent studies in high fat diet (HFD)-fed mice show that CAP also alters gut microbiota composition and causes weight loss in HFD-fed mice. Many studies have suggested that short-chain fatty acids (SCFAs) mediate the links between diet, gut microbiota, and fat storage. Objective T

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