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To evaluate the effectiveness of desensitizing agents in reducing dentine permeability. The efficacy of desensitizing agents in reducing dentine permeability by occluding dentine tubules was evaluated using a fluid filtration device that conducts at 100 cmH O (1.4 psi) pressure, and SEM/EDX analyses were evaluated and compared. Forty-two dentine discs ( = 42) of 1 ± 0.2 mm width were obtained from caries-free permanent human molars. Thirty dentine discs ( = 3 were randomly divided into 3 groups ( = 1 Group 1 2.7% wt. monopotassium-