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Overall, the present study unraveled the molecular responses at protein and metabolite levels, which provided a better understanding of toxicological effects and mechanisms of TCPP in marine teleost. Caribou (Rangifer tarandus) are a culturally significant food resource for communities in northern Canada and Greenland. Many barren-ground caribou subpopulations are currently in decline, some dramatically; understanding the influence of stressors, such as toxic trace metals, is important. These contaminants enter Arctic terrestrial environ