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Striking therapeutic advancements have changed the clinical course of SMA dramatically, although supportive care continues to play an important role in patient care. Striking therapeutic advancements have changed the clinical course of SMA dramatically, although supportive care continues to play an important role in patient care. This article reviews the clinical features, diagnostic approach, and treatments available for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The article also provides an update on the