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These modifications will eventually lead to the anorexic activity of FX.Analgesic device of Botulinum toxin type A (BoNT/A) involves retrograde axonal transportation to central nervous system, where it might probably communicate with sensory neurons. Though, some writers proposed that BoNT/A antinociceptive action can also be associated with the inhibition intracellular factors and neuromodulators expressed by resistant cells, particularly by microglia. Antigen-induced joint dis