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15, p = .0145) and p-tau (β -0.17, p = .0052). As for lipids, higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were associated with decreased CSF t-tau (TC β -0.16, p = .0115; LDL-C β -0.16, p = .0082) and p-tau (TC β -0.15, p = .0177; LDL-C β -0.14, p = .0225) in obese participants. Furthermore, these associations were only significant in participants with late-life obesity and APOE-ɛ4 non-carriers. Overall, in a cognitively normal population, we found metabolically healthy obesity and lipids in lat