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A systematic search up to March 2019 was done in Embase, PubMed, PsycINFO, CINAHL, Cochrane Library, Scopus, and Luxid. Randomized and quasirandomized tests reporting neonatal pain machines had been included. Assessment of this studies for addition, data removal, and high quality evaluation was done separately by 2 researchers. Of 3718 tests found, 352 with 29,137 infants and 22 posted pain scales had been included. Most researches (92%) worried procedural discom