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In this context, we examined the result of knockdown of A-kinase anchor necessary protein 4 on mobile pattern, apoptosis, mobile expansion, colony development, migration, and intrusion in triple-negative cancer of the breast cells. We also examined the synergistic cytotoxic effect of paclitaxel on A-kinase anchor necessary protein 4 downregulated triple-negative breast cancer cells. Knockdown of A-kinase anchor protein 4 lead to significant decrease in cellular growth and migratory capabilit