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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person has both ADHD and depression or anxiety treating one condition usually improves the other. Mental health experts prescribe antidepressants and stimulants for depression, or antidepressants along with ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently prescribed antidepressants that are prescribed "off-label" for ADHD. These medications increase the levels of neurotransmitters dopamine and norepinephrine. They also improv