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A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prevents T-cell proliferation in vitro and in vivo. These effects were observed only when 4MU was added prior to initial antigen presentation but not later, consistent with 4MU-mediated inhibition of

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How to Get Tested For ADHD If you are struggling to stay organized or focused, it is time to get your ADHD evaluated. Learn more about the ADHD evaluation process. A health professional uses a multistep evaluation to determine whether someone has symptoms of attention-deficit/hyperactivity disorder. This may include a medical exam and behavioral evaluations, as well as tests that are standardized. 1. Self-assessment In a self-assessment, you rate your performance on a particular task or activity. Then, you set goals or plans to improve yo